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Farnesoid X Receptor Activity
Farnesoid X Receptor Activity
The farnesoid X receptor (FXR) is a type of nuclear receptor found in human liver cells that regulates transcription of genes involved in several metabolic pathways, making FXR a focal point in the world of drug design. FXR is the focus of my ongoing research project in the Okafor laboratory at Penn State, which investigates the role that interactions between FXR’s different domains play in the transcriptional role of this receptor. This research proposal, which was written as a part of the application for the Department of Biochemistry and Molecular Biology’s Summer Undergraduate Research Funding (SURF) grant, includes the background, hypothesis, and methods to be used for this project, along with a brief discussion of potential outcomes, to gain funding to work on this project over the summer 2025 semester.
Endothelial Cell Behavior
Endothelial Cell Behavior
Endothelial cells, which line the insides of your blood vessels, are exposed to shear stresses as a result of blood flow. As a result, it is difficult to investigate these cells in a laboratory setting in a condition reflective of their natural state. This research poster, which I co-authored in high school at Bucknell University’s Ultrasound and Mechanobiology lab, was presented at the Biomedical Engineering Society’s 2023 annual meeting, and it presents the details of a new microfluidics system that exposes endothelial cells to shear stresses similar to those they would experience in blood vessels, allowing their behavior to be investigated under realistic conditions. The poster highlights the details of the project, including the operation, results, and the effectiveness of this device, along with the steps taken to make it operate effectively.
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